Expression of cyclooxygenase-2 in breast cancer

Objective:To study the expression of cyclooxygenase-2 (COX-2) in breast cancer tissue and normal epithelial tissue,and to study the relationship between COX-2 and the prognosis of the breast cancer.Methods:The primary breast cancer(n=98) and adjacent normal epithelial tissue(n=20) were analyzed for COX-2 expression by immunohistochemical method using specific monoclonal antibodies.Results:The expression of COX-2 in breast cancer and normal epithelial tissue had significant difference in statistics(P0.05).A significant correlation was found between the survival period and pathological stage,estrogen receptor positive and P185 positive(RR=1 6.619,0.377,2.952 respectively).The five-year-survival rate of COX-2 positive expression was 80.9%,and 93.3% for negative expression(Log-Rank test,P=0.34)Conclusion:The cyclooxygenase-2 may be participated the whole course of carcinogenesis of breast cancer,but not is absolute factor for estimate the survival rate of the patients with breast cancer.