The Expression of COX-2、P53 and MDR-1/P-gp in Breast Cancer

Objective To detect the expression of COX-2、P53 and MDR-1/P-gp in breast cancer and their correlations.Methods Immunohistochemistry analyses was used to detect the expression of COX-2、P53 and MDR-1/P-gp in 66 cases of breast cancer without chemotherapy.Results 1.These positive rate of COX-2、P53 and MDR-1/P-gp protein in breast cancer tissue were 62.1%(41/66)、50%(33/66)and 40.9%(27/66)respectively.2.The over-expression of COX-2 protein was positively correlated with the expression of P53 and MDR-1/P-gp protein.(r=0.281 and 0.332,P0.006).3.The over-expression of P53 protein was positively correlated with the expression of MDR-1/P-gp protein(r=0.277,P=0.024).Conclusions Determination of the above genes expression in breast cancer tissue can be of use in deciding the degree of malignancy and prognosis of brest cancer.COX-2、P53 and MDR-1/P-gp expression may be closely related to diagnosis and prognosis of patients.They might be biomarkers and as therapeutic targets in breast cancer.Research on the above genes expression and their relationship can provide molecular basis for clinical practice.