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Protective Effect of Ulinastatin in the Ischemia-reperfusion Injury of Rat Pancreas

Ren Yonghua -

Abstract

Objective To study the effect of ulinastatin during ischemia-reperfusion injury of rat pancreas. Mothods 72 SD rats were randomly divided into pseudoperation group,ischima-reperfusion group and ulinastatin group. Serum TNF-α and IL-1β were determined during the pancreas ischemia and reperfusion in 0,6,12 and 24 hour respectively. Results The expression level of TNF-α and IL-1β in ischemia-reperfusion group were obviously higher than pseudoperation group and ulinastatin group(P0.05). Conclusion Ulinastatin can suppress the inflammatory reaction during the pancreas ischemia and reperfusion and has protective effects on rat pancreas ischemia-reperfusion injury.

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Available abstract

Key concepts: Ulinastatin, Medicine, Ischemia, Pancreas, Reperfusion injury, Anesthesia, Internal medicine