2010•Chinese Journal of Hospital PharmacyRequires access

Protective effect of ulinastatin on ischemia and reperfusion of heart in rats

Dezhong Wang, Zhang Li-ping

Abstract

OBJECTIVE:To study the protective effects of different doses of ulinastatin on ischemia and reperfusion injury of heart in SD rats.METHODS:Fifty SD rats were randomly divided into five groups: the normal control group(A),ischemia and reperfusion group(B),high dose ulinastatin group(C),middle dose ulinastatin group(D),low dose ulinastatin group(E).And the animals were killed after 40 min ischemia of heart followed by reperfusion for 2 h.TNF-αand IL-8 were detected,and apoptosis of heart muscle were observed.RESULTS:After ischemia and reperfusion,the serum level of TNF-αand IL-8 remarkedly decreased,and the index of apoptosis significantly reduced.CONCLUSION:Ulinastatin has dose-related protective effects on rat heart ischemia and reperfusion injury.

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Key concepts: Ulinastatin, Ischemia, Medicine, Reperfusion injury, Anesthesia, Apoptosis, Pharmacology, Internal medicine