Investigation on preparation and in vitro properties of sinomenine hydrochloride binary ethosomes

Objective To screen the optimal formulation for preparing sinomenine hydrochloride binary ethosomes and to explore its properties in vitro.Methods The binary ethosomes were prepared by ethanol injection method with ethanol and propylene glycol as the softeners.An orthogonal test was used to optimize the formulation with entrapment efficiency as the index.The shape,Zeta potential,size and in vitro drug release were analyzed.Results The prepared binary ethosomes were spherical in shape.The average entrapment efficiency of the optimal formulation was(35.43±0.53)% with Zeta potential of-(5.87±0.06)mV and mean size of(391.6±1.70)nm.The drug release in vitro was fitted the first-order equation:Q=0.085t+0.739,r=0.9958.Conclusion Sinomenine hydrochloride binary ethosomes are easy to be prepared and have a sustained release property in vitro.