Expression of Cox-2 and EZH2 in mucoepidermoid carcinoma of salivary glands

【Objective】 To explore the expression of cyclooxygenase-2(Cox-2) and its enhancer of zester homologue(EZH2) in mucoepidermoid carcinoma(MEC).【Methods】 PV-6001 two-step immunohistochemical assay was used to test the expression of Cox-2 and EZH2 in 34 cases of MEC and 11 cases of normal salivary gland tissue(NSG),and SPSS16.0 software was used for statistical analysis.【Results】 The expression level of Cox-2 and EZH2 in the MEC was significantly higher than that in the NSG group(P 0.01).Cox-2 expressed the high,middle and low differentiated group and recurrent group and metastasized tissue(P 0.05,P 0.01).There was statistical difference of the expression of EZH2 not only among the high,middle and low differentiated group but also in localization and recurrence and metastasis of MEC(P 0.01,P 0.05).The expression of Cox-2 and EZH2 in MEC was positively correlated(rs = 0.680,P 0.01).【Conclusions】 It is suggested that Cox-2 and EZH2 expressed in MEC related to its localization,recurrence and metastasis.The expression of EZH2 might be related with the localization of MEC.And the examination of Cox-2 combined with EZH2 in the MEC might be a useful approach for determining its diagnosis,management and prognosis.