Expression and Significance of Cox-2 and EZH2 in Salivary Duct Carcinoma

Objective: To examine the expression of Cox-2 and EZH2 in salivary duct carcinoma(SDC) and normal salivary gland(NSG),and to investigate the relationship between the expression of two proteins and pathological type,gender,tumor size,recurrence as well as metastasis.Methods: The expression of Cox-2 and EZH2 was detected among 14 NSG and 37 SDC samples by immunohistochemical method.Results: Significant differences in the expression of Cox-2 and EZH2 were found between SDC and NSG samples.In SDC,significant differences in the expression of Cox-2 and EZH2 were also found between mastoid and essential types,as well as between sieve pore and essential types,tumor size,recurrence and metastasis.The expression of Cox-2 in SDC was positively correlated with EZH2.Conclusion: Compared to NSG,the expression of Cox-2 and EZH2 significantly increase in SDC.And their expressions are associated with pathological type,tumor size,recurrence and metastasis.Moreover,Cox-2 and EZH2 are co-expressed.Co-detection of Cox-2 and EZH2 is helpful to the diagnosis,therapy,and prognosis judgment of SDC.