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2009•China Practical MedicineRequires access

A controlled study on the treatment of depression with duloxetine and paroxetine

Zhang Fu-y

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Abstract

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression.Methods 66 patients who met CCMD-3 criterion for depression episode were randomly assigned to duloxetine group(n=34)and paroxetine group(n=32)for the treatmentof 6 weeks.The clinical efficacy was evaluated by HAMD.The side effects were evaluated by TESS.Results The efficacy was similar for the two drugs.The efficacious rate was 73.5% and the adverse events rate was 41.2%for duloxetine.No significant difference was founded in the adverse events between the two groups Conclusion Duloxetine is an effective drug for depression with good tolerance.

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What this paper is about

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression.Methods 66 patients who met CCMD-3 criterion for depression episode were randomly assigned to duloxetine group(n=34)and paroxetine group(n=32)for the treatmentof 6 weeks.The clinical efficacy was evaluated by HAMD.The side effects were evaluated by TESS.Results The efficacy was similar for the two drugs.The efficacious rate was 73.5% and the adverse events rate was 41.2%for duloxetine.No significant difference was founded in the adverse events between the two groups Conclusion Duloxetine is an effective drug for depression with good tolerance.

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Available abstract

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression.Methods 66 patients who met CCMD-3 criterion for depression episode were randomly assigned to duloxetine group(n=34)and paroxetine group(n=32)for the treatmentof 6 weeks.The clinical efficacy was evaluated by HAMD.The side effects were evaluated by TESS.Results The efficacy was similar for the two drugs.The efficacious rate was 73.5% and the adverse events rate was 41.2%for duloxetine.No significant difference was founded in the adverse events between the two groups Conclusion Duloxetine is an effective drug for depression with good tolerance.

Key concepts: Duloxetine, Medicine, Hamd, Paroxetine, Depression (economics), Adverse effect, Clinical efficacy, Internal medicine

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