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A double-blind study of duloxetine in the treatment of depression

Zhao Xing

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Abstract

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression. Method 68 patients with depression were randomly divided into study group(duloxetine)and control group(fluxetine),and treated for 6 weeks.Efficacy and side effects were assessed with HAMD,HAMA,CGI-SI,and AE respectively before and after treatment.Results The efficacy was similar for the two drugs.The efficacious rate was 85.3% and the adverse events rate was 41.2% for duloxetine.No significant difference was found in the adverse events between the two groups.Conclusion Duloxetine is an effective drug for depression,with good tolerance.

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What this paper is about

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression. Method 68 patients with depression were randomly divided into study group(duloxetine)and control group(fluxetine),and treated for 6 weeks.Efficacy and side effects were assessed with HAMD,HAMA,CGI-SI,and AE respectively before and after treatment.Results The efficacy was similar for the two drugs.The efficacious rate was 85.3% and the adverse events rate was 41.2% for duloxetine.No significant difference was found in the adverse events between the two groups.Conclusion Duloxetine is an effective drug for depression,with good tolerance.

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Available abstract

Objective To evaluate the efficacy and safety of duloxetine in the treatment of depression. Method 68 patients with depression were randomly divided into study group(duloxetine)and control group(fluxetine),and treated for 6 weeks.Efficacy and side effects were assessed with HAMD,HAMA,CGI-SI,and AE respectively before and after treatment.Results The efficacy was similar for the two drugs.The efficacious rate was 85.3% and the adverse events rate was 41.2% for duloxetine.No significant difference was found in the adverse events between the two groups.Conclusion Duloxetine is an effective drug for depression,with good tolerance.

Key concepts: Duloxetine, Medicine, Hamd, Depression (economics), Adverse effect, Internal medicine, Clinical efficacy, Duloxetine Hydrochloride

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