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A clinical control study of Duloxetine and paroxetine in the treatment of depression

LI Ya-ju

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Abstract

Objective To compare clinical efficacy and side effects between Duloxetine and paroxetine in the treatment of depression in outpatients.Methods 62 patients who met CCMD-2-R for de-pression were randomly assigned to 2 groups.One group was treated with Duloxetine and the otherwith paroxetine for six weeks.Hamilton rating scale(HAMD),clinical global impression scale(CGI),and treatment emergent symptom scale(TESS) were used to assess.Results Total clinical effectiverate was 80% for Duloxetine group and 87% for paroxetine group.There were no differences in clinicaleffects and adverse reactions between the two groups.Conclusion The results indicate that Duloxetine is a safe and effective drug for the treatment of depression in outpatients.

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What this paper is about

Objective To compare clinical efficacy and side effects between Duloxetine and paroxetine in the treatment of depression in outpatients.Methods 62 patients who met CCMD-2-R for de-pression were randomly assigned to 2 groups.One group was treated with Duloxetine and the otherwith paroxetine for six weeks.Hamilton rating scale(HAMD),clinical global impression scale(CGI),and treatment emergent symptom scale(TESS) were used to assess.Results Total clinical effectiverate was 80% for Duloxetine group and 87% for paroxetine group.There were no differences in clinicaleffects and adverse reactions between the two groups.Conclusion The results indicate that Duloxetine is a safe and effective drug for the treatment of depression in outpatients.

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Available abstract

Objective To compare clinical efficacy and side effects between Duloxetine and paroxetine in the treatment of depression in outpatients.Methods 62 patients who met CCMD-2-R for de-pression were randomly assigned to 2 groups.One group was treated with Duloxetine and the otherwith paroxetine for six weeks.Hamilton rating scale(HAMD),clinical global impression scale(CGI),and treatment emergent symptom scale(TESS) were used to assess.Results Total clinical effectiverate was 80% for Duloxetine group and 87% for paroxetine group.There were no differences in clinicaleffects and adverse reactions between the two groups.Conclusion The results indicate that Duloxetine is a safe and effective drug for the treatment of depression in outpatients.

Key concepts: Duloxetine, Paroxetine, Medicine, Hamd, Clinical Global Impression, Depression (economics), Rating scale, Clinical efficacy

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