Clinical significance of fibrosis index in the treatment of fibrosis of chronic hepatitis B

Objective To investigate the clinical significance of hepatic fibrosis index from hepatitis B virus e antigen(HBeAg) negative patients with chronic hepatitis B(CHB) in the clinical treatment of liver fibrosis.Methods The changes of hepatic fibrosis index,serum liver fibrosis indicators,width of portal vein diameter,thickness of the spleen and liver function were examined and compared before and after treatment with liver-protective drugs in 30 patients diagnosed as HBeAg negative CHB.Results Compared to before,hepatic fibrosis index,serum liver fibrosis indicators,thickness of the spleen and liver function were significantly improved after treatment(P0.05),whereas there was no significant difference in width of portal vein diameter(P0.05).ConclusionHepatic fibrosis index can reflect the changes of liver fibrosis simply,dynamically and comprehensively,which is valuable in evaluating the efficacy of treatment.