Study on preparation and in vitro dissolution of curcumin-plasdone solid dispersion

OBJECTIVE To prepare solid dispersion for increasing the dissolution of curcumin.METHODS Using polyvinyl pyrrolidone(PVPk30) as the carrier,solid dispersion was prepared by solvent evaporation method.The differential scanning calorimeter(DSC) and powder X-ray diffractometry(PXRD) were used to identify the state of the drug existence in the solid dispersion.The in vitro dissolution characteristics were studied in artificial gastric juice.RESULTS Curcumin existed as amorphous or molecular state in the solid dispersion.The in vitro dissolution rates of curcumin from all solid dispersions were larger than the pure drug and higher carrier-Curcumin ratio led to faster drug dissolution.The solubility of curcumin was improved by the solid dispersion and reached 66.28 g·L-1 in water.CONCLUSION The solid dispersion prepared with PVP could increase the dissolution of curcumin.