Preparation of Curcumin Solid Dispersion Systems and Their Dissolution Test in vitro

Objective: To enhance the dissolution rate of Curcumin(Cur) by solid dispersion technique.Methods: Solid dispersion(SD) of Curcumin was prepared with PVPk30 or Chitosan and characterized by differential scanning calorimetry.Results: The result of differential scanning calorimetry indicated that in Cur-PVPk30(1∶3) solid dispersion Cur existed as an amorphous form and in Cur-Chitosan(1∶1)solid dispersion,Cur was finely crystalline.Dissolution measurements demonstrated that a significantly increased dissolution rate was obtained with solid dispersion compared to the physical mixture.Conclusion: Curcumin solid dispersion can significantly increase its dissolution rate.