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Preparation of orally disintegrating tablets of ambroxol hydrochloride

Yi Tao

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Abstract

Objective:To design an formula of ambroxol hydrochloride orally disintegrating tablets.Method: By using orthogonal design,different formula and active ingredients according to the characteristics of orally disintegrating tablets were evaluated by the effect of disintegrating behavior and time limit observed.Results: The optimal formulation composed of mannitol 30g,cellulose microcrystallisate(MCC) 50 g,hydroxypropyl cellulose(L-HPC) 8 g and sodium bicarbonate 1 g.Conclusion: The disintegrating time of the tablets meet the qualification standard,and it have superior taste and dissolution rate compared with normal tablets.

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What this paper is about

Objective:To design an formula of ambroxol hydrochloride orally disintegrating tablets.Method: By using orthogonal design,different formula and active ingredients according to the characteristics of orally disintegrating tablets were evaluated by the effect of disintegrating behavior and time limit observed.Results: The optimal formulation composed of mannitol 30g,cellulose microcrystallisate(MCC) 50 g,hydroxypropyl cellulose(L-HPC) 8 g and sodium bicarbonate 1 g.Conclusion: The disintegrating time of the tablets meet the qualification standard,and it have superior taste and dissolution rate compared with normal tablets.

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Available abstract

Objective:To design an formula of ambroxol hydrochloride orally disintegrating tablets.Method: By using orthogonal design,different formula and active ingredients according to the characteristics of orally disintegrating tablets were evaluated by the effect of disintegrating behavior and time limit observed.Results: The optimal formulation composed of mannitol 30g,cellulose microcrystallisate(MCC) 50 g,hydroxypropyl cellulose(L-HPC) 8 g and sodium bicarbonate 1 g.Conclusion: The disintegrating time of the tablets meet the qualification standard,and it have superior taste and dissolution rate compared with normal tablets.

Key concepts: Ambroxol, Sodium bicarbonate, Chromatography, Dissolution, Chemistry, Pharmacology, Medicine, Organic chemistry

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