Preparation of Propranolol hydrochloride orally disintegrating tablets and evaluation of its quality

OBJECTIVE To study the formulation and preparation of Propranolol hydrochloride orally disintegrating tablets,and to evaluate its quality.METHODS The formulation of orally disintegrating tablets was optimized by orthogonal experiment design according to the indexes of disintegrating time and appearance.The tablets were prepared by a direct powder compression technique.The properties of the tablets,such as disintegrating time in vitro and the dissolution profile,were determined.RESULTS The orally disintegrating tablets were integrit and smooth with desirable taste in the mouth.The disintegrating time was less than 15 s,and the cumulative dissolution percentage was higher than 98.45% within 2 min.CONCLUSION The prescription and formulation described here appears promising in Propranolol hydrochloride orally disintegrating tables with good quality.