The Curative Effect of Sertraline combined with Quetiapine in the Treatment of 60 Patients with Poststroke Depression

Objective To observe the curative effect of sertraline combined with quetiapine in the treatment of patients with poststroke depression.Methods 60 patients with poststroke depression hospitalized in the first time in our hospital whose course of disease was 6 months to 2 years,were divided into control group(sertraline group) and observation group(sertraline combined with quetiapine group),and each group has 30 patients.Six weeks after treatment,the clinical effect of patients were measured with Hamilton 17 depression scale(HAMD-17).Results After the treatment,the scores of HAMD-17 of both groups were decreased significantly.The improvement at each time point between two groups were significance(F=126,P0.05).In the observation group,descending trend all showing significant deviation after treatment for 2,4,6 weeks compared with that in the control group(P0.05).The clinic efficiency of the observation group were apparently superior to that of the control group.There were significantly statistical differences between the two groups(H=5.67,P0.05).And without obvious adverse reactions in the two groups.Conclusion Sertraline combined quetiapine in the treatment of poststroke depression have better clinical results,was worthy of clinical application.