2010•Shiyong yixue zazhiRequires access

The efficacy and safety of paliperidone extended-release tablets for first-episode schizophrenia

Zhe Chen

Abstract

Objective To investigate the efficacy and safety of paliperidone extended-release tablets for first-episode schizophrenia.Methods 90 patients with first-episode were randomly assigned to receive paliperidone extended-release tablets (study group,45 patients),or risperidone (control group,45 patients) for 8 weeks.The efficacy and safety of the therapies were assessed by Positive and Negative Syndrome scale (PANSS) and Treatment Emergent Symptom Scale (TESS) at weeks 0,2,4,and 8.Results 82 patients completed 8 weeks of treatment.Compared to the data before treatment,PANSS at weeks,2,4,6 and 8 had obvious difference (P 0.01).Compared with control group,Incident of extrapyramidal side effects and abnormal liver function was lower.Conclusions Paliperidone extended-release tablets is effective and safe in the treatment of schizophrenia.

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Key concepts: Paliperidone, Risperidone, Schizophrenia (object-oriented programming), Extrapyramidal symptoms, Positive and Negative Syndrome Scale, Medicine, Internal medicine, Paliperidone Palmitate