Efficacy and safety of paliperidone extended-release tablets in the treatment of patients with schizophrenia

Objective: To explore efficacy and safety of palipefidone extended-release(ER) tablets in the treatment of patients with schizophrenia.Methods: Totally 79 schizophrenic patients were treated with paliperidone ER tablets for 6 weeks.They were assessed with Positive and Negative Symptoms Scales(PANSS),Treatment Emergent symptom Scale(TESS) and Personal and Social Performance(PSP).Results: In the end of the 2nd or 6th weeks of treatment with palipefidone ER tablets,the total and factor scores of PANSS were significantly lower than those in baseline(P0.05),and the scores of PSP were significantly higher than those of control group(P0.05).The common adverse events were extrapyramidal symptoms,insomnia,constipation and prolactin increasing in paliperidone ER group.Conclusion: Paliperidone ER tablets are effective to improve positive symptoms,negative symptoms and social functions of patients with schizophrenia with high safety.