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2011•Journal of psychiatryRequires access

A control study of paliperidone extended-release tablets and olanzapine in the treatment of first-episode schizophrenia

Zha Zhi-qun

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Abstract

Objective To compare efficacy and safety of paliperidone extended-release tablets and olanzapine in the treatment of first-episode schizophrenia.Methods 90 adult patients with first-episode schizophrenia in accordance with CCMD-Ⅲ were randomized into study group treated with paliperidone extended-release tablets and control group treated with olanzapine for 8 weeks.The Positive and Nenative Syndrome Scale(PANSS) and Treatment Emergent Side effect Scale(TESS) were used to evaluate efficacy and side effects respectively at the baseline and at the ends of the 2nd,4th and 8th weekends of the treatment.Results There was no significant difference in effective rate between study group and control group(91.2% vs.96.5%,P0.05).Total score and factor scores of PANSS at each interview-point showed no significant differences between the two groups(P0.05).The incidence rate of side effects in both groups was low and the severity was mild.Conclusion Paliperidone extended-release tablets have equivalent efficacy and safety in the treatment of first-episode schizophrenia.

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Objective To compare efficacy and safety of paliperidone extended-release tablets and olanzapine in the treatment of first-episode schizophrenia.Methods 90 adult patients with first-episode schizophrenia in accordance with CCMD-Ⅲ were randomized into study group treated with paliperidone extended-release tablets and control group treated with olanzapine for 8 weeks.The Positive and Nenative Syndrome Scale(PANSS) and Treatment Emergent Side effect Scale(TESS) were used to evaluate efficacy and side effects respectively at the baseline and at the ends of the 2nd,4th and 8th weekends of the treatment.Results There was no significant difference in effective rate between study group and control group(91.2% vs.96.5%,P0.05).Total score and factor scores of PANSS at each interview-point showed no significant differences between the two groups(P0.05).The incidence rate of side effects in both groups was low and the severity was mild.Conclusion Paliperidone extended-release tablets have equivalent efficacy and safety in the treatment of first-episode schizophrenia.

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Available abstract

Objective To compare efficacy and safety of paliperidone extended-release tablets and olanzapine in the treatment of first-episode schizophrenia.Methods 90 adult patients with first-episode schizophrenia in accordance with CCMD-Ⅲ were randomized into study group treated with paliperidone extended-release tablets and control group treated with olanzapine for 8 weeks.The Positive and Nenative Syndrome Scale(PANSS) and Treatment Emergent Side effect Scale(TESS) were used to evaluate efficacy and side effects respectively at the baseline and at the ends of the 2nd,4th and 8th weekends of the treatment.Results There was no significant difference in effective rate between study group and control group(91.2% vs.96.5%,P0.05).Total score and factor scores of PANSS at each interview-point showed no significant differences between the two groups(P0.05).The incidence rate of side effects in both groups was low and the severity was mild.Conclusion Paliperidone extended-release tablets have equivalent efficacy and safety in the treatment of first-episode schizophrenia.

Key concepts: Olanzapine, Paliperidone, Positive and Negative Syndrome Scale, Schizophrenia (object-oriented programming), Medicine, Extended release, Negative symptom, Internal medicine

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