Effect of propofol combined with small doses of butorphanol on painless artificial abortion

Objective To explore the feasibility as well as the advantages and disadvantages of propofol combined with small doses of butorphanol on painless abortion.Methods 160 cases of early-pregnant women with ASA(grade I) were randomly divided into four groups(40 cases each group).Patients in group A accepted 0.001 mg/kg fentanyl followed by propofol intravenously;Patients in group B accepted intravenous propofol;Patients in group C and D accepted 0.01 mg/kg or 0.02 mg/kg butorphanol before intravenous propofol respectively.The initial dose of propofol in group B was 2.5 mg/kg and 2 mg/kg in others,and additional doses will be applied when body motion occurred.The changes of respiratory and circulatory function,anesthesia and analgesia effects,postoperative recovery profile and side-effects were observed before and after anesthesia.Results The operations were successful in all the patients.Each group showed circulatory depression to a certain extent after anesthesia,and the most one was group B(P0.05).The incidence of respiratory depression in group A was the highest(P0.01).And the incidence of intraoperative insufficient analgesia and postoperative abdominal pain in group B was the most significant(P0.05).In addition,the awake time and departure time was the longest in group D(P0.05).Conclusion Propofol combined with small doses of butorphanol(0.01 mg/kg) can fulfill the requirement for painless artificial abortion.This anesthetic combination can decrease the incidence of insufficient analgesia and respiratory depression compared with using propofol or fentanyl alone.Therefore,it is suitable to apply anesthetic compatibility in the painless artificial abortion.