Dose optimization of butorphanol combined propofol anesthesia in painless induced abortion

Objective To investigate the effects and safety of butorphanol and propofol in operation of painless induced abortion.Methods 150 ASA I～Ⅱ patients undergoing outpatient painless induced abortion were randomly divided into five groups according to different dose of butorphanol.Followed by intravenous injection of propofol 2mg/kg,the patients were induced with butorphanol 0,5,10,15,20μg/kg in group P,B5,B10,B15,B20 respectively.Anesthesia was maintained with propofol when needed.The following were recorded and compared in each group: the time of unconsciousness,operation time,recovery time from anesthesia,discharge time;hemodynamic changes during anesthesia and the total doses of propofol;anesthesia satisfaction rating,VAS of pain and the side effects.Results Anesthesia satisfaction rating,recovery time from anesthesia and the total doses of propofol were significantly improved in group B5,B10,B15,B20(P0.05).Conclusion with group B5,Anesthesia satisfaction rating was better and the total doses of propofol was less in group B10,B15,B20(P0.05).However,there were no significant difference among group B10,B15 and B20 regarding VAS of pain(P0.05).The incidence of respiratory depression was significantly higher in group B15 and B20 compared with group B5 and B10(P0.05).Conclusion 10μg/kg butorphanol combined with propofol anesthesia appears to be superior for painless induced abortion,with regards to better anesthetic effects and less adverse effects.