2013•Qilu yixue zazhiRequires access

EXPRESSIONS OF Notch1 AND C-erBb-2 IN BREAST CARCINOMA

Hai-Yan Gu

Abstract

Objective To investigate the relationship between expressions of Notch1 and C-erBb-2 protein in breast carcinoma,and explore the correlation between the two markers.Methods The expressions of Notch1 and C-erBb-2 in 60 breast cancers and 20 of paraneoplastic tissue were detected by immunohistochemical method.Results The positive expressions of both Notch1 and C-erBb-2 in the cancer were obviously higher than that in paraneoplastic normal breast tissue(χ2=29.511,29.474;P0.01).The expression of Notch1 was related to clinical staging and lymph node metastasis(χ2=5.881,4.716;P0.05),and that of C-erBb-2 related with whether or not the lymph node was involved(χ2=8.341,P0.05).The expression of Notch1 was positively correlated with C-erBb-2 in breast cancer(r=0.451,P0.01).Conclusion The high expressions of Notch1 and C-erBb-2 are associated with the occurrence,development and metastasis of breast cancer,a combined detection of these two markers is conducive to predicting the potential of metastasis and prognosis of this malignancy.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Medicine, Immunohistochemistry, Breast cancer, Breast carcinoma, Malignancy, Lymph node, Lymph node metastasis, Metastasis