EFFECT OF FOUR KINDS OF IN HEMODYNAMIC ANESTHESIA INDUCTION AND TRACHEAL INTUBATION IN HEMODYNAMIC

Objective To compare the effects of the etomidate、propofol、midazolam and propofol +midazolam on the hemodynamic response during induction and intubation of general anesthesia.Methods Sixty patients,ASAI-II,22-60Y,were divided ramdomly into four groups: groupA(etomidate,n=15),groupB(midazolam,n=15),groupC(propofol),group D(midazolam+propofol).Patients received fentenyl 3 μg /kg,vecuronium 0.1 mg/kg,etomidate 0.3 mg/kg in group A,midazolam 0.3 mg/kg in group B,propofol 2mg/kg in group C,midazolam 0.1mg/kg+propofol 1mg/kg in group D for induction and intubation at 5min after induction.The vital signs(BP,HR,Spo2) during induction and intubation were recored.Results After induction,the BP and HR decreased in all groups.It singnificantly decreased in group B and C(p0.05).The BP and HR were ascended in all groups after intubating it was significantly different with perinduction in group A(p0.01).it was no significantly different between perinduction and postinduction in groupB、C and D.Conclusion The etomidate could not depress the hight haemodynamic response to laryngoscopy and tracheal intubation effectively;propofol、midazolam and propofol+midazolam could depress the haemodynamic response to laryngoscopy and tracheal intubation effectively,but propofol+midazolam has more stability haemodynamic.