2005Zhongguo jiceng yiyaoRequires access

A comparison of effects of propofol,etomidate or midazolam on circulation system of elderly patients during induction and intubation of general anesthesia

张舟, 郑良杰

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Abstract

目的 比较异丙酚、依托咪酯、咪唑安定全麻诱导插管对老年患者循环系统的影响.方法 65岁以上择期行全麻手术患者90例,ASA Ⅰ~Ⅲ级,随机平均分为异丙酚组(A组)、依托咪酯组(B组)、咪唑安定组(C组).麻醉诱导:静脉全麻药A组异丙酚2 mg/kg、B组依托咪酯0.3 mg/kg、C组咪唑安定0.3 mg/kg,合用诱导药物均为阿曲库铵0.6 mg/kg、芬太尼3 μg/kg,诱导后5 min进行气管插管.监测和记录麻醉前后各时点的BP、HR及脉搏氧饱和度(SpO2),观察患者有无不良反应及气管插管应激反应等.结果诱导后三组患者血压和心率均下降,至插管前下降幅度最大,A、C组下降明显,差异有显著意义,B组差异无显著意义.插管后三组血压和心率均上升,A、C组与插管前比较差异有显著意义,三组血压与基础值比较差异无显著意义.结论对于高龄患者进行静脉全身麻醉诱导时,选用依托咪酯较异丙酚和咪唑安定安全。

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目的 比较异丙酚、依托咪酯、咪唑安定全麻诱导插管对老年患者循环系统的影响.方法 65岁以上择期行全麻手术患者90例,ASA Ⅰ~Ⅲ级,随机平均分为异丙酚组(A组)、依托咪酯组(B组)、咪唑安定组(C组).麻醉诱导:静脉全麻药A组异丙酚2 mg/kg、B组依托咪酯0.3 mg/kg、C组咪唑安定0.3 mg/kg,合用诱导药物均为阿曲库铵0.6 mg/kg、芬太尼3 μg/kg,诱导后5 min进行气管插管.监测和记录麻醉前后各时点的BP、HR及脉搏氧饱和度(SpO2),观察患者有无不良反应及气管插管应激反应等.结果诱导后三组患者血压和心率均下降,至插管前下降幅度最大,A、C组下降明显,差异有显著意义,B组差异无显著意义.插管后三组血压和心率均上升,A、C组与插管前比较差异有显著意义,三组血压与基础值比较差异无显著意义.结论对于高龄患者进行静脉全身麻醉诱导时,选用依托咪酯较异丙酚和咪唑安定安全。

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Available abstract

目的 比较异丙酚、依托咪酯、咪唑安定全麻诱导插管对老年患者循环系统的影响.方法 65岁以上择期行全麻手术患者90例,ASA Ⅰ~Ⅲ级,随机平均分为异丙酚组(A组)、依托咪酯组(B组)、咪唑安定组(C组).麻醉诱导:静脉全麻药A组异丙酚2 mg/kg、B组依托咪酯0.3 mg/kg、C组咪唑安定0.3 mg/kg,合用诱导药物均为阿曲库铵0.6 mg/kg、芬太尼3 μg/kg,诱导后5 min进行气管插管.监测和记录麻醉前后各时点的BP、HR及脉搏氧饱和度(SpO2),观察患者有无不良反应及气管插管应激反应等.结果诱导后三组患者血压和心率均下降,至插管前下降幅度最大,A、C组下降明显,差异有显著意义,B组差异无显著意义.插管后三组血压和心率均上升,A、C组与插管前比较差异有显著意义,三组血压与基础值比较差异无显著意义.结论对于高龄患者进行静脉全身麻醉诱导时,选用依托咪酯较异丙酚和咪唑安定安全。

Key concepts: Etomidate, Medicine, Midazolam, Propofol, Anesthesia, Intubation, Sedation

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A comparison of effects of propofol,etomidate or midazolam on circulation system of elderly patients during induction and intubation of general anesthesia — Research Paper | ScholarLens