A clinical effects comparison of propofol auto-co-induction and midazolam propofol co-induction

Objective:To compare the clinical effects of propofol auto-co-induction and midazolam propofol co-induction. Methods:90 elective operation patients of ASAⅠ-Ⅱ grade aged 18～55 years were divided randomly into three groups, M-P group(midazolam propofol co-induction group),P-P group (propofol auto-co-induction group) and P group (propofol induction group). Patients in M-P group were received midazolam 3mg, patients in P-P group were received pre-administering propofol 30 mg given as a bolus before anesthesia was induced with intravenous propofol and patients in P group were received intravenous propofol directly. Mean arterial pressure (MAP) and heart rate of all patients were monitored before induction and intubation. Results:The induction dose of propofol required in M-P group or P-P group was smaller than that of P group. The decrease in MAP and HR was significantly smaller in M-P group when compared to P group. There was no statistical difference in MAP and HR reduction between P-P group and P group. There was a significantly greater in MAP and HR decreases when P-P group was compared to M-P group. Conclusions:Either midazolam propofol co-induction or pre-administering propofol auto-co-induction can decrease the dose of propofol required to induce anesthesia, but when compared to midazolam propofol co-induction, pre-administering propofol auto-co-induction had no benefit to maintain hemodynamics stability.