Effects of Curative Methods with Tonifying the Kidney and Promoting Blood Circulation by Removing Blood Stasis on Cytokine Production in Intraperitoneal Fluid of Endometriosis Model Rats

Objective To investigate the effects of different herbs on the cytokine variation in intraperitoneal fluid of endometriosis model rats. Methods 24 model rats with endometriosis were separated randomly into 4 groups (n=6): group A treated with tonifying the kidney and promoting blood circulation, group B with promoting blood circulation by removing blood stasis, group C with simple tonifying the kidney, and group D with normal saline as control. The levels of IFN-r, IL-2 and IL-10 in intraperitoneal fluid were detected. Results The levels of IFN-r and IL-2 increased and IL-10 decreased significantly in group A compared with the control group (P0.01). There was not significant difference in IFN-r, IL-2 and IK-10 between group B or C and the control group. Conclusions The curative effect of tonifying the kidney and promoting blood circulation is better than promoting blood circulation by removing blood stasis or simple tonifying the kidney in the treatment of endometriosis.