Effect of Jiangzhi Decoction on Vascular Endothelial Function and HsCRP of Patients with Hyperlipidemia

Objective:To investigate the effect of Jiangzhi decoction on lipid levels,vascular endothelial function and hsCRP of Patients with hyperlipidemia.Method:Sixty patients with primary hyperlipidemia were randomly divided into treatment group(n=30) and control group(n=30).The treatment group was treated with lipid-lowering soup side(recipe granules),once daily.The control group was treated with simvastatin,20 mg once daily,all for 8 weeks.Lipid levels were measured;blood endothelin(ET) was determined by radioimmunoassay;serum nitric oxide(NO) was observed by nitrate reduction method;high-sensitivity C-reactive protein(hs-CRP) was monitored by ELISA;and endothelium-dependent flow-mediated diastolic function(FMD) was also detected.Result:After treatment,in both groups,TC,TG,LDL-C were decreased significantly,HDL-C was increased significantly.No significant difference appeared between the two groups after treatment.In the two groups,ET-1 and hs-CRP were significantly lowered,NO and FMD was significantly increased.ET-1 and FMD of the treatment group showed significant difference compared with those in the control group(P0.05).Conclusion:Jiangzhi decoction can improve the status of patients with hyperlipidemia.It is likely related to improvement in endothelial function and decrease in plasma hs-CRP level.