Clinical characteristics of moyamoya disease and its DSA analysis:a study of 36 patients

Objective To study the clinical characteristics of moyamoya disease and the features of digital subtraction angiography(DSA).Methods ①The clinical characteristics of 36 patients who were diagnosed as having moyamoya disease by DSA were summarize,and their data of angiography were analyzed simultaneously.Results Clinical characteristics:the age of onset of moyamoya disease had two peaks(around 5~10 years old and 30~35 years old).Twenty-seven patients(75%)manifested as cerebral ischemia,7(19%)as cerebral hemorrhage,and 2(6%)as symptomatic epilepsy;15 children(≤ 15 years old,42%),and 21 adults(15 year old,58%).Their types of diseases were mainly cerebral ischemia,and their most common clinical manifestations were unilateral limb weakness or hemiplegia.②The DSA features in 22 patients(61%)were bilateral internal carotid arteries stenosis or occlusions on the distal segments,and in 14 patients(39%)were affected on one side.Unilateral or bilateral anterior cerebral artery,middle cerebral artery and posterior cerebral artery existed various degrees of stenosis or occlusive lesions,accounting for 50%(18 patients),56%(20 patients)and 17%(6 patients),respectively;All patients existed various degrees of abnormal vascular networks at the base of the brain.In addition,the patients in this group had abundant collateral circulation:such as moyamoya vessel compensation at the base of the brain in 36 patients(100%),opened collateral(cortical)branches in 26 patients(72%),ophthalmic artery branches compensation in 3 patients(8%),and external carotid artery system compensation in 19 patients(53%).Conclusions The age of onset of moyamoya disease has two peaks.The clinical manifestations of the disease are various,but cerebral ischemia is the most common feature.Because moyamoya disease can be diagnosed definitely by DSA,so in patients clinically suspected of having this disease DSA should be performed as early as possible.