Study on clinical manifestations and imaging characteristics of 30 Moyamoya disease patients

Objective Purposes of this paper was to study the clinical manifestations and imaging characteristics and the relation ship between the patients with moyamoya disease. Methods The clinical characteristics of 30 patients who were diagnosed as moyamoya disease by magnetic resonance angiography (MRA) and digital subtraction angiography (DSA) were summarized, and their data of angiography were analyzed simultaneously. Results (1) The age of onset of moyamoya disease had one peak in adults (around 35～45 years old ). The cerebral ischemia was main type of disease.The main clinical manifestations were unilateral limb weakness or hemiplegia. (2) On CT and MRI,there were cerebral hemorrhage in 7 patients(36.7%) and cerebral infarction in 10 patients(33.3%),cerebral hemorrhage and cerebral infarction in 5 patients. On MRA and DSA,unilateral or bilateral anterior cerebral artery, middle cerebral artery and posterior cerebral artery existed stenosis or occlusive lesions, bilateral arterial stenosis or occlusion was more than unilateral arterial. moyamoya abnormal vessels were showed in the basal ganglia in 5 patients(45.5%)and 29 patients(100%)especially. On DSA,in all patients,posterior communicating artery was dilated in 13 patients,and anterior communicating artery was dilated in 7 patients,ophthalmic artery(OPHA) was dilated in 6 patients,and leptomeningeal collateral vessels were dilated in 4 patients. The collateral circulation was very bad in 4 patients with excessive cerebral infarction in our study. Conclusion The age of onset of moyamoya disease has one peak in the adults. The clinical manifestations of the disease are various, but cerebral ischemia is the most common feature. MRI and MRA are no vasion and the preferred method for screening test,diagnosis and follow-up survey in this disease. DSA should be performed as early as possible in patients clinically suspected of having moyamoya disease.