2005•Unpublished venueRequires access

Protection of breviscapine against lipid peroxidation damage of liver

Mingyan Zhang

Abstract

Objective:To explor the effect of breviscapine(Bre) on lipid peroxidation in hepatic ischemia-reperfusion injury(HIRI).Methods:The HIRI model was used.Sixteen rabbits were randomly divided into control group(n=8) and Bre group(n=8).The superoxide dismutase(SOD) activity,malondialdehyde(MDA) content in hepatic tissue were observed,and obsvered the cell structure of the liver microscope at reperfusion 60 min.Results:The SOD activity and MDA content of Bre group,as compared with control group,showed significant differences(P0.01).The change of the cell structure in Bre group is lighter than in the control group.Conclusion:Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.liver;reperfusion injury;superoxide dismutase;malondialdehyde;drugs,chinese nerbal

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Key concepts: Malondialdehyde, Lipid peroxidation, Superoxide dismutase, Chemistry, Reperfusion injury, Dismutase, Radical, Biochemistry