Surveillance on measles antibody level in healthy population and serological effect of intensive immunization with measles vaccine

Objective To study the effect of intensive immunization with measles vaccine and the measles antibody level in healthy population. [Methods] ELISA was adopted to detect the measles IgG-antibody of the randomly selected 1 534 healthy people between the age of 0 to 39 from 2 counties. [Results] The antibody positive rate was 77.57% (1 190/1 534); GMT was 1:783. The antibody positive rate was the highest among children between the age of 1 to 12 (85.71%～98.44%). GMT began to descend to middle and low level from 6 years old. The antibody positive rate showed a decreasing tendency along with the increase of age. The success rate of the first vaccination on 188 children aged from 8～12 months was 96.81%; the success rate of revaccination on 186 children aged from 5～7 years old was 61.29%; The GMT after the first and second vaccination increased by 28.4 and 3.1 times respectively. [Conclusion] The measles antibody level of older children and adults can only reach the middle and low level. Whether in the first vaccination or revaccination, those whose antibody was in middle and low level may have a significantly higher success rate than those with high level of antibody.