Zinc on Experimental Diabetic Rats Antioxidantion Effects

Observed the effect of Zn2+on alloxan-induced diabetic rat's antioxidantion.Injected 200 mg/kg Alloxan to intraperitoneal by once to establish the diabetes model rat,using zinc and metformin by daily oral administration,continuing four weeks,using weekly orbital blood,detected the red blood cells of rats superoxide dismutase(SOD),liver SOD and plasma lipid peroxidation products(MDA).The results,10 mg/kg·d ZnSO4 Group,100 mg/kg·d metformin and 5 mg/kg ZnSO4 Group,100 mg/kg· d metformin and 5 mg/kg ZnSO4 Group red blood cells superoxide dismutase(SOD),liver SOD were significantly higher the diabetes model rat group and MDA is significantly lower than diabetes model rat group(P0.05 or0.01).That zinc on experimental diabetic rats increased SOD,reduce MDA generated a certain role,and it combined with metformin the effect will better.