Prognostic value of procalcitonin and endotoxin concentrations for intra-abdominal sepsis

Objective To evaluate the value of serum procalcitonin and endotoxin concentrations in prognosis of intra-abdominal sepsis. Methods A total of 86 patients with intra-abdominal sepsis were included into the study. We compared PCT and endotoxin concentrations according to classification of different outcomes( survivors and nonsurvivors) and intra-abdominal sepsis( local infections,sepsis,severe sepsis and septic shock). The correlation of PCT or endotoxin concentrations to APACHE Ⅱ or SOFA score were also analyzed,then see their function in judging the prognosis of sepsis. Results Nonsurvivors had a higher level of PCT than survivors. PCT concentrations was higher in patients with severe sepsis and septic shock than that with sepsis or local infections. PCT concentrations was associated with APACHE Ⅱ and SOFA score significantly,but not endotoxin. The area under ROC curve for predicting 28-days mortality of PCT,endotoxin,APACHE Ⅱ and SOFA score were 85. 7%,56. 3%,86. 7% and 86. 0%,respectively. Conclusion PCT had a higher prognostic value in intra-abdominal sepsis than endotoxin.