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2004•Bulletin of Chinese CancerRequires access

The Effects of Urineside on Immunity of Patients with Advanced Non-small Cell Lung Cancer

Jinbo Zhao

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Abstract

To evaluate the effect of Urineside on immunity of patients with advanced non-small cell lung cancer.Forty-five patients with advanced non-small cell lung cancer were enrolled.Twenty-six patients received chemotherapy with NVB+DDP and 19 patients received the same regiment combined with Urineside for 4 to 8 weeks.The changes of T-lymphocyte subgroups were measured with the flow cytometry method before and after 2 cycles chemotherapy in the patients.The ratio of CD4+/CD8+ in patients with advanced non-small cell lung cancer before chemotherapy was significantly lower than that in control group(P0.05). In the chemotherapy group, the count of CD3+?CD4+ cells and the ratio of CD4+/CD8+ lowered after chemotherapy(P0.05), that indicates the immunity decreased after chemotherapy.In the Urineside group,no significant changes of CD3+ cells and the ratio of CD4+/CD8+ pre- and post-treatment were observed (P0.05), the immunity had no significant changes.After chemotherapy,CD3+ and CD4+ cells and the ratio of CD4+/CD8+ of the two groups had significant difference,the immunity in Urineside group was obviously higher than that in chemotherapy group.[Conclusion]The immunity is suppressed in the patients with advanced non-small cell lung cancer.The immunity lowers after chemotherapy.Urineside can improve the cell immunity in patients undergoing chemotherapy.

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What this paper is about

To evaluate the effect of Urineside on immunity of patients with advanced non-small cell lung cancer.Forty-five patients with advanced non-small cell lung cancer were enrolled.Twenty-six patients received chemotherapy with NVB+DDP and 19 patients received the same regiment combined with Urineside for 4 to 8 weeks.The changes of T-lymphocyte subgroups were measured with the flow cytometry method before and after 2 cycles chemotherapy in the patients.The ratio of CD4+/CD8+ in patients with advanced non-small cell lung cancer before chemotherapy was significantly lower than that in control group(P0.05). In the chemotherapy group, the count of CD3+?CD4+ cells and the ratio of CD4+/CD8+ lowered after chemotherapy(P0.05), that indicates the immunity decreased after chemotherapy.In the Urineside group,no significant changes of CD3+ cells and the ratio of CD4+/CD8+ pre- and post-treatment were observed (P0.05), the immunity had no significant changes.After chemotherapy,CD3+ and CD4+ cells and the ratio of CD4+/CD8+ of the two groups had significant difference,the immunity in Urineside group was obviously higher than that in chemotherapy group.[Conclusion]The immunity is suppressed in the patients with advanced non-small cell lung cancer.The immunity lowers after chemotherapy.Urineside can improve the cell immunity in patients undergoing chemotherapy.

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Available abstract

To evaluate the effect of Urineside on immunity of patients with advanced non-small cell lung cancer.Forty-five patients with advanced non-small cell lung cancer were enrolled.Twenty-six patients received chemotherapy with NVB+DDP and 19 patients received the same regiment combined with Urineside for 4 to 8 weeks.The changes of T-lymphocyte subgroups were measured with the flow cytometry method before and after 2 cycles chemotherapy in the patients.The ratio of CD4+/CD8+ in patients with advanced non-small cell lung cancer before chemotherapy was significantly lower than that in control group(P0.05). In the chemotherapy group, the count of CD3+?CD4+ cells and the ratio of CD4+/CD8+ lowered after chemotherapy(P0.05), that indicates the immunity decreased after chemotherapy.In the Urineside group,no significant changes of CD3+ cells and the ratio of CD4+/CD8+ pre- and post-treatment were observed (P0.05), the immunity had no significant changes.After chemotherapy,CD3+ and CD4+ cells and the ratio of CD4+/CD8+ of the two groups had significant difference,the immunity in Urineside group was obviously higher than that in chemotherapy group.[Conclusion]The immunity is suppressed in the patients with advanced non-small cell lung cancer.The immunity lowers after chemotherapy.Urineside can improve the cell immunity in patients undergoing chemotherapy.

Key concepts: Chemotherapy, Immunity, CD8, Medicine, Lung cancer, Internal medicine, Cellular immunity, Oncology

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