Preparation Technology of Shuyankang Dispersible Tablets

Objective To establish the preparation techniques of Shuyankang dispersible tablets.Methods The extraction process was set up based on the herbal properties.The preparation process was screened by single factor test and orthogonal design.A comprehensive scoring analysis was performed with disintegrating time and dispersible uniformity as the indexes.Results Shuyankang thick paste was extracted by alcohol and water,then added microcrystalline cellulose with the proportion of 20 %.After completely mixing,the mixture was dried at 60 ℃,crushed to cross the 60 eyelets sieve,thus the dry extract powder was obtained.The crosslinked polyvinyl pyrrolidon and Gum Acacia were added to the dry extract in the proportion of 5 % and 0.3 %.After mixing,the mixture powder was made into tablets directly and the rigidity of the tablets was required in 3～ 4 kg· cm-2.The prepared dispersible tablet could be totally disintegrated within three minutes and crossed No.2 sieve,which subjected to the Chinese pharmacopoeia.Conclusions The dispersible tablets are in accordance with the standard,and have stable quality.