Comparative Study of Captopril Triple Therapy for Senile Patients with Different Types of Essential Hypertension

Objective To find out the efficacy and safety of single low-dose captopril triple therapy for senile patients with different types of essential hypertension.Methods Totally 156 aged patients with essential hypertension were divided into two groups,84 aged patients with isolated systolic hypertension(ISH) in group A and 72 aged patients with systolic/diastolic hypertension(SDH) in group B.All of the patients were given a test dose of 25mg oral captopril,12.5mg hydrochlorothiazide and 40mg isosorbide mononitrate per day in the morning.The course of the treatment was 8 weeks.Serum lipid,pulse pressure and blood biochemistry index were observed,and the antihypertensive effect and safety were summarized.Results After 8 weeks treatment,systolic pressure descended distinctly(P0.01),but diastolic pressure was indistinctly(P0.05) in group A.Systolic pressure and diastolic pressure were both decreased significantly(P0.01) in group B.The pulse- pressure-decreasing effect of group A was very significant(P0.01) and the difference was very remarkable as compared with that of group B(P0.01).Conclusion It is safe and effective to use single low-dose captopril triple therapy for senile patients with isolated systolic hypertension(ISH) and systolic/diastolic hypertension(SDH);and the therapy has a significant curative effect on senile patients with isolated systolic hypertension(ISH).