2007•Journal of the Medical Sciences (Berkala Ilmu Kedokteran)Open access

Study on pharmacokinetics of xuesaitong tablet after a single oral dose in dog plasma

Jiliang Xu

Abstract

Objective:To study the pharmacokinetics of xuesaitong tablet in dog plasma.Methods:6 dogs received single-oral-dose xuesaitong tablets and plasma concentrations were determined by HPLC.Results:The main pharmacokinetics parameters of xuesaitong tablets were that tmax was(56.7±5.2) min,Cmax was(15.49±3.14) ng/μL,t1/2 was(55.66±13.64) min,and AUC(0→4h) was(1543.93±157.07) ng·min/μl.Conclusion:The method is highly sensitive,rapid,simple and specific enough to determine pharmacokinetics.

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Key concepts: Pharmacokinetics, Medicine, Cmax, Plasma concentration, Pharmacology, Plasma levels, Oral dose, Internal medicine