In vivo pharmacokinetics of Xuesaitong pulsatile-release tablets in dogs

Objective To study the in vivo pharmacokinetics and bioavailability of Xuesaitong pulsatile-release tablets. Methods Six dogs were randomly given Xuesaitong pulsatile tablets and conventional tablets 50 mg, and plasma concentrations of Xuesaitong in the dogs were quantified by HPLC. The in vivo pharmaceutical behavior of the tablets was evaluated with lag time, Cmax, and AUC. Results Xuesaitong tablets(lag 6 h in vitro) were released at 4.4 h while the lag time of conventional tablets was 0.2 h in the dogs. No statistical difference was found for Cmax, AUC and so on. Conclusion Pulsatile-release tablets meet the requirements of design.