Pharmacokinetics of Oxymatrine Sustained-release Tablets in Dogs

Pharmacokinetics of oxymatrine sustained-release tablets and its capsules were investigated in six dogs for a single oral dose and multiple oral doses, respectively. The concentration of oxymatrine in plasma was determined by HPLC. The results showed that the concentration-time curves conformed to two-compartment model. The pharmacokinetic parameters after single dose were Kα(0.60±0.11) and (1.22±0.11)h-1, Tmax (2.83±0.26) and (1.58±0.20)h, Cmax(1.96±0.73) and (3.06±0.42)μg/ml for test and reference drugs, respectively. The relative bioavailability of test drug was(90.22±5.7)%. After treated with multiple oral doses for 4 days, the concentration of oxymatrine got to a steady-state level,with FI of (1.37±0.35) and (1.59±0.40)for test and reference drugs, respectively.