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2006•Chongqing yixueRequires access

Apoptosis of Jurkat cells induced by daunorubicin in vitro

Xinghua Chen

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Abstract

Objective To study the rule of apoptosis of Jurkat induced by daunorubicin(DNR).Methods Apoptosis of Jurkat cells stained with Annexin V/PI was detected by flow cytometry.Cell cycle distribution of Jurkat cells was analyzed by flow cytometry after cell stained with PI.Results The increase of apoptotic Jurkat cells percentage was in direct proportion to DNR doses within 0.1-2.0μmol/L as well as exposure period.Jurkat cells exposed to DNR were demonstrated increased in the G_2/M phase.Conclusion Apoptosis of Jurkat cells induced by DNR could be related to the inhibition mitosis of Jurkat cells.

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Objective To study the rule of apoptosis of Jurkat induced by daunorubicin(DNR).Methods Apoptosis of Jurkat cells stained with Annexin V/PI was detected by flow cytometry.Cell cycle distribution of Jurkat cells was analyzed by flow cytometry after cell stained with PI.Results The increase of apoptotic Jurkat cells percentage was in direct proportion to DNR doses within 0.1-2.0μmol/L as well as exposure period.Jurkat cells exposed to DNR were demonstrated increased in the G_2/M phase.Conclusion Apoptosis of Jurkat cells induced by DNR could be related to the inhibition mitosis of Jurkat cells.

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Available abstract

Objective To study the rule of apoptosis of Jurkat induced by daunorubicin(DNR).Methods Apoptosis of Jurkat cells stained with Annexin V/PI was detected by flow cytometry.Cell cycle distribution of Jurkat cells was analyzed by flow cytometry after cell stained with PI.Results The increase of apoptotic Jurkat cells percentage was in direct proportion to DNR doses within 0.1-2.0μmol/L as well as exposure period.Jurkat cells exposed to DNR were demonstrated increased in the G_2/M phase.Conclusion Apoptosis of Jurkat cells induced by DNR could be related to the inhibition mitosis of Jurkat cells.

Key concepts: Jurkat cells, Apoptosis, Flow cytometry, Daunorubicin, Annexin, Molecular biology, Cell cycle, Cell biology

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