Clinical Significance and Expression of CD_(44s) and CD_(44v6) in Colorectal Lesion

Objective:To invesgatethe the significance of the expression of CD44s and CD44v6 in colorectal adenocarcinomas.Methods:To detect the CD44s and CD44v6 proteins in 85 cases of colorectal adenocarcinomas,28 cases of colorectal adenonoma with dysplasia,and 36 cases peripheral normal mucosa of cancer by SP (streptavidinHRP) immunohistochemical method.Result:The postive expression rate of CD44s and CD44v6 was 67.1% and 92.9% in cancer foci,respectively,and 66.7% and 88.9% in adenoma withdysplasia,respectively.It was significant comparing with the postive rate of the normol mucosa(P0.01).As well as,the over-expression of CD44v6 was related with Duke′s stage of colorectal adenocarcinoma(P0.01).Furthermore,the expression of CD44v6 was higher in those patients with less 5 years survival(P0.05) But both the CD44s and CD44v6 were not related with the differentiation,lymph node and distand metastasis of colorectal adenocarcinoma.Conclusion:The expression of CD44s and CD44v6 proteins has a significance in early diagnosis of colorectal adenocarcinoma,especially CD44v6 and the detecting of CD44v6 protein is a possibal prognostic factor of colorectal adenocarcinoma.