Expression and clinicopathologic significance of CD44v6 and p27 in colorectal carcinomas

Objective To observe the expression and reveal clinical significance of CD44v6 and p27 in colorectal carcinoma.Methods Collecting 50 cases of fresh specimen of colorectal carcinoma and normal mucous from excision operation.CD44v6 expression was detected by means of FCM in 50 cages of colorectal carcinoma and corresponding normal mucous.p27 protein was studied by SP immunohistochemical method.Analysis of statistics was performed by combining clinical and patholoical materials.Results CD44v6 and p27 expression in colorectal carcinoma was significantly higher than that in normal mucous (P＜0.01).As well as the expression of CD44v6 and p27 was obviously associated with differentiated grade,lymph node metastasis,distant metastasis and Dukes stage(P＜0.05).The expression of CD44v6 was not evidently correlated with the depth of tumor invasion(P＞0.05).but the expression of p27 Was correlated with the depth of tumor invasion(P＜0.05).Conclusion The expression of CD44v6 and p27 is markedly related with clinicopathological characters of colorectal carcinoma.CD44v6 expression and p27 expression axe obvious negative relationship in colorectal carcinoma.There is a certain value of reference for assessing the malignant grade and the potential of recurrence and metastasis,evaluating patient prognosis and selecting rational treatment after operation. Key words: Intestinal neoplasms; Flow cytometry; Immuno histochemistry; Antigen; CD44; p27