The effects of decoction and total phenol extract from Magnolia Officinalis Cortex on gastrointestinal motility and gastric electrical activity

Objective To investigate the effect of decoction and total phenol extract from Magnolia Officinalis Cortex on gastiointestinal motility and gastric electrical activity. To explore the scientific connotation that Magnolia Officinalis Cotex has the efficacy of promoting Qi circulation to relieve flatulence and the connection between its efficacy and pungent flavor. Methods The black semisolid nutrient paste was intragastrically given to the mice and gastric emptying and small intestine propulsion were detected at the same time; the frequency of rat's slow wave in gastric eletrogram were detected by BL- 420 E + biological skills analysis system,to investigate the influence of decoction and total phenols extract of Magnolia Officinalis Cotex on it. Results Compared to the reference group,treated with physiological saline,Domperidone,Magnolia Officinalis Cotex decoction( 3. 00 g / kg) and total phenol extract of Magnolia Officinalis Cotex( 7. 00 × 10- 2g / kg) could remarkably reduce the gastric residual rate and enhance the small intestine propulsion of mice( P 0. 01,P 0. 05). In addition,Domperidone,Magnolia officinalis Decoction( 3. 00 g / kg,1.5g / kg) and total phenol extract of Magnolia Officinalis Cotex( 7. 00 × 10- 2g / kg,3. 50 × 10- 2g / kg) could remarkably increase the frequency of rat's slow wave in gastric eletrogram( P 0. 01,P 0. 05). Conclusion The connection between the efficacy and pungent flavor of Magnolia Officinalis Cotex is prospectively associated with the promotion of the frequencies of rat's slow wave in gastric eletrogram and then enhance gastrointestinal motility,and the total phenol extract may be the functional substantial basis.