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2013•Journal of Lanzhou UniversityRequires access

Effect of Pingweisan on gastric emptying in rat

Bin Duan, Zhang Jian-qiang, Ming Chen, Wei Yu-hui, Xinan Wu

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Abstract

Objective To investigate the effects of Pingweisan and the each herbal drugs decoction on gastric emptying in rats.Methods After orally administrating decoction 7 d,~(99m)Tcpentetate acid and stannous chloride for injection were orally administrated and the residual ~(99m)Tc-pentetate acid and stannous chloride for injection in rat gastric were scanned by single photo emission computed tomography.The half gastric emptying time(T_(1/2)) was calculated. Results After administration a dose of 200 mg/(kgd) of different drugs,the T_(1/2) of Pingweisan, Atractylodes iancea,Magnolia officinalis,Citrus reticulate and Glycyrrhiza uralensis were about 23.17,19.95,22.13,27.53 min.T_(1/2) for positive control group was 22.13 min while for the negative control group it was about 58.06 min.Conclusion The decoction of Pingweisan,Atractylodes iancea,Magnolia officinalis and Citrus reticulate have a strong effect on gastric emptying in rat.

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Objective To investigate the effects of Pingweisan and the each herbal drugs decoction on gastric emptying in rats.Methods After orally administrating decoction 7 d,~(99m)Tcpentetate acid and stannous chloride for injection were orally administrated and the residual ~(99m)Tc-pentetate acid and stannous chloride for injection in rat gastric were scanned by single photo emission computed tomography.The half gastric emptying time(T_(1/2)) was calculated. Results After administration a dose of 200 mg/(kgd) of different drugs,the T_(1/2) of Pingweisan, Atractylodes iancea,Magnolia officinalis,Citrus reticulate and Glycyrrhiza uralensis were about 23.17,19.95,22.13,27.53 min.T_(1/2) for positive control group was 22.13 min while for the negative control group it was about 58.06 min.Conclusion The decoction of Pingweisan,Atractylodes iancea,Magnolia officinalis and Citrus reticulate have a strong effect on gastric emptying in rat.

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Available abstract

Objective To investigate the effects of Pingweisan and the each herbal drugs decoction on gastric emptying in rats.Methods After orally administrating decoction 7 d,~(99m)Tcpentetate acid and stannous chloride for injection were orally administrated and the residual ~(99m)Tc-pentetate acid and stannous chloride for injection in rat gastric were scanned by single photo emission computed tomography.The half gastric emptying time(T_(1/2)) was calculated. Results After administration a dose of 200 mg/(kgd) of different drugs,the T_(1/2) of Pingweisan, Atractylodes iancea,Magnolia officinalis,Citrus reticulate and Glycyrrhiza uralensis were about 23.17,19.95,22.13,27.53 min.T_(1/2) for positive control group was 22.13 min while for the negative control group it was about 58.06 min.Conclusion The decoction of Pingweisan,Atractylodes iancea,Magnolia officinalis and Citrus reticulate have a strong effect on gastric emptying in rat.

Key concepts: Glycyrrhiza uralensis, Decoction, Gastric emptying, Reticulate, Traditional medicine, Medicine, Atractylodes, Oral administration

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