Effect of Magnoliae Officinalis Cortex on Stomach Dynamic and Ulcer in Rat before and after its Diaphoretic Processing

Objective:The influences of Magnoliae Officinalis Cortex on stomach dynamic and ulcer in ratsbefore and after its diaphoretic processing were investigated.Method: The gastric motility disorder in SD rats was established by injecting L-Arg intraperitoneally for five days,then the rats were given the extract of Magnoliae(Magnoliae Officinalis Cortex 10 g · kg-1) by intragastric administration,the extract of diaphoretic Magnoliae(diaphoretic Magnoliae Officinalis Cortex 10 g · kg-1) was gived by intragastric administration,cisapride(0.004 g · kg-1) by intraperitoneal injection,respectively,gastric residual rate was determined,then improving effect by Magnolia Officinalis Cortex before and after its diaphoretic processing was observed.Kunming mice were given 0.35 mL 0.6 mol · L-1 hydrochloric acid by ig,HCI-induced gastric ulcer was established.mice were given 10 g · kg-1 indomethacin by ip and 0.15 mL 50% ethanol by ig,indomethacin-ethanol-ulcer was established,and antiulcer effect between pre-and post treatment of diaphoretic Magnoliae Officinalis Cortex was observed by giving the extract of Magnoliae Officinalis Cortex(Magnoliae Officinalis Cortex 10 g · kg-1),the extract of diaphoretic Magnoliae Officinalis Cortex(diaphoretic Magnoliae Officinalis Cortex 10 g · kg-1),0.04 g·kg-1 ranitidine hydrochloride for continuous 3 d.Result: Gastrointestinal motility in rats injected by L-Arg intraperitoneally was slowed down,plasma motilin was reduced.The extract of Magnoliae Officinalis Cortex,the extract of diaphoretic Magnoliae Officinalis Cortex could effectively inhibit the decrease in Gastrointestinal motility(P0.05) and plasma motilin(P0.05),and there was a significant difference between the diaphoretic Magnoliae Officinalis Cortex group and the Magnoliae Officinalis Cortex group,and the diaphoretic Magnoliae Officinalis Cortex groupand the group cisapride(P0.05).Gastric residual rate in the extract of Magnoliae Officinalis Cortexand the extract of diaphoretic Magnoliae Officinalis Cortex group,cisapride was(70.2±14.1)%,(61.5±12.8)%,(71.3±12.4)% respectively;plasma motilin was(84.8±11.6),(92.9±11.7),(85.4±12.1)nmol · L-1.Both Magnoliae Officinalis Cortex and diaphoretic Magnoliae Officinalis Cortex could reduce the index of HCl-ulcer and indomethacin-ethanol-ulcer(P0.01),and the index of HCl-ulcer and indomethacin-ethanol-ulcer of diaphoretic Magnoliae Officinalis Cortex was smaller to that of Magnoliae Officinalis Cortex(P0.01).The index of HCl-ulcer in the extract of Magnoliae Officinalis Cortex,the extract of diaphoretic Magnoliae Officinalis Cortex and ranitidine hydrochloride groups was(36.8±10.4),(29.5±8.2),(17.5±10.1)mm respectively;indomethacin-ethanol-ulcer were(45.4±11.7),(33.8±11.0),(20.3±4.9)mm.Conclusion: Diaphoretic Magnoliae Officinalis Cortex is better than Magnoliae Officinalis Cortex on improving the gastric motility disorder and antiulcer effect,so processing technology of diaphoretic Magnolia Officinalis Cortex is necessary.