Effect of Xingnaojing on the Level of Serum S-100B Protein in Patients with Acute Cerebral Infarction

Objective:To explore the effect of Xingnaojing on the level of serum S-100B protein and recovery of neurological function.Methods:157 Patients with acute cerebral infarction were randomly assigned to receive Xingnaojing(30 mg by intravenous drip twice a day) for 14 days or placebo.We obtained serum S-100B protein of the patients at admission time and 24,48,72,96,120 and 144 hours after admission.National institutes health stroke scale scores(NIHSS scores) were evaluated at hospital admission and 1,2,4,14 days after admission.Results:Values of serum S-100B in two groups raised until 4th day,peak value of treatment group was statistically lower than the control one.There were differences in the two groups(P 0.05).The S-100B serum value obtained 144 h after stroke in treatment group was higher than the control group.There were significant differences in the two groups(P 0.01).NIHSS scores in two groups decreased after admission at 1,4,7 and 14 days,scores in the treatment group at 1,4,7 and 14 days were lower than the control group(P0.05).Conclusion:Xingnaojing can decrease NIHSS score,improve neurological function and decrease S-100B serum concentration.