Correlations of serum 25-hydroxyvitamin D with disease severity and outcome of acute cerebral infarction

Objective To investigate the correlation between serum serum 25-hydroxyvitamin(D25[OH]D)and severity of disease and outcome in acute cerebral infarction.Methods Serum 25(OH)D was measured in 130acute cerebral infarction patients.According to the different concentration of vitamin D,the patients were divided into A group(sufficient≥75nmol/L),B group(critical 50.0-74.9nmol/L),C group(unsufficient≤49.9nmol/L).All of patients were evaluated by National Institutes of Health Stroke Scale(NIHSS)and Barthel index(BI)on admission and two weeks after treatment.The prognosis was judged according to the NIHSS value.Results There were significant difference in NIHSS and BI score among three groups on admission and two weeks after treatment(P 0.05).NIHSS and BI score of A group were obviously higher than those in B group,C group.Serum 25(OH)D was negative correlated with NIHSS score,but positive correlated with BI score on admission and two weeks after treatment.The case numbers of basic recovery,significant progress,progress in A group were significantly higher than those in B group and C group.The case numbers of no change,deterioration in A group,B group were significantly lower than those of C group.Conclusion 25(OH)D is a risk factor for acute cerebral infarction,and it is an objective index to judge severity and prognosis of the disease.