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2005•Journal of Modern StomatologyRequires access

Expression and significance of Tie-2 receptor in oral squamous cell carcinoma

Nan Xin-rong

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Abstract

Objective To investigate the role of Tie-2 receptor in oral squamous cell carcinoma.Methods Tie-2 and CD34 protein expression in 34 oral squamous cell carcinoma(OSCC) and 16 oral normal mucosa were detected by SABC immunohistochemical technique.Results Tie-2 and CD34 expressed at higher level in OSCC than in the control oral mucosa(P0.05);but expression of Tie-2 and CD34 was not significantly positive correlated with pathological grade in OSCC(P0.05).Conclusion Angiogenesis is increased in OSCC,and Tie-2 may be involved in the OSCC angiogenesis regulation.

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What this paper is about

Objective To investigate the role of Tie-2 receptor in oral squamous cell carcinoma.Methods Tie-2 and CD34 protein expression in 34 oral squamous cell carcinoma(OSCC) and 16 oral normal mucosa were detected by SABC immunohistochemical technique.Results Tie-2 and CD34 expressed at higher level in OSCC than in the control oral mucosa(P0.05);but expression of Tie-2 and CD34 was not significantly positive correlated with pathological grade in OSCC(P0.05).Conclusion Angiogenesis is increased in OSCC,and Tie-2 may be involved in the OSCC angiogenesis regulation.

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Available abstract

Objective To investigate the role of Tie-2 receptor in oral squamous cell carcinoma.Methods Tie-2 and CD34 protein expression in 34 oral squamous cell carcinoma(OSCC) and 16 oral normal mucosa were detected by SABC immunohistochemical technique.Results Tie-2 and CD34 expressed at higher level in OSCC than in the control oral mucosa(P0.05);but expression of Tie-2 and CD34 was not significantly positive correlated with pathological grade in OSCC(P0.05).Conclusion Angiogenesis is increased in OSCC,and Tie-2 may be involved in the OSCC angiogenesis regulation.

Key concepts: CD34, Basal cell, Angiogenesis, Immunohistochemistry, Pathological, Oral mucosa, Pathology, Medicine

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