2008•Acta Academiae Medicinae ZunyiRequires access
Interaction of fluorine, calcium and iodine on thyroid weights of rats
LI Ji-rong
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Abstract
Objective To study the interaction of fluorine, calcium and iodine on thyroid weights of rats. Methods Wistar rats were randomly divided into 8 groups: ①moderate concentrations of fluorine, calcium and iodine; ②moderate concentrations of fluorine, iodine and higher concentration of calcium; ③moderate concentrations of calcium, iodine and higher concentration of fluorine; ④moderate concentration of iodine and higher concentrations of fluorine, calcium; ⑤moderate concentrations of fluorine, calcium and lower concentration of iodine; ⑥moderate concentration of fluorine, higher concentration of calcium and lower concentration of iodine; ⑦moderate concentration of calcium, higher concentration of fluorine and lower concentration of iodine; ⑧higher concentrations of fluorine, calcium and lower concentration of iodine based on 2×2×2 factorial design. After six months, thyroid weights were measured. Results According to the results of factorial ANOVA, significant interaction effects of fluorine with calcium and calcium with iodine were found. Thyroid weights in lower concentration of iodine group is higher than that in moderate concentration of iodine group, while certain fluorine and calcium concentrations were moderate. Thyroid weights in moderate concentration of calcium group is lower than that in higher concentration of calcium group, while certain iodine concentration were moderate and fluorine concentration were higher. Thyroid weights in higher concentration of fluorine group is lower than that in moderate concentration of fluorine, while certain iodine and calcium concentrations were moderate. Thyroid weights in moderate concentration of fluorine group is lower than that in higher concentration of fluorine, while certain iodine concentration were moderate and calcium concentration were higher. No effect were found in other groups. Conclusions interaction effects of fluorine with calcium and calcium with iodine were found in thyroid weight, and this effect could affected growth and development of thyroid directly or indirectly.