The Antitumor Effect of Capilliposide on Nasopharyngeal Cancer Cell Line CNE-2 in vitro

[Purpose] To observe the antitumor activity of capilliposide on human nasopharyngeal cancer cell lines CNE-2. [Methods] CNE-2 cells were cultured with different concentrations with capilliposide. Cell proliferation were measured by MTT assay,colony formation by a soft agar assay and apoptosis by flow cytometry. [Results] The survival rate of CNE-2 cells was significantly decreased after incubation with capilliposide,and the IC50in 48 hours was 7.4μg/ml. After 8μg/ml concentrations treatment,the number of colony-formation in soft agar of the CNE-2 cells was 297±24,which was lower than that in control group( 119±11). Apoptosis rate was 16.43%±3.1% in capilliposide group and 9.34%±2.3% in control group.[Conclusion] Capilliposide plays a role in growth inhibition and inducing apoptosis in human nasopharyngeal cancer cell line CNE-2.